Authorities have identified the victim as 16-year-old Kyah Kinkade of rural Kearney.
Shortly after 11:30 p.m., local fire crews were called to the family home located at 5379 Bison Run after flames broke out inside the structure.
Three of the four family members were able to escape the fire without injury, but the girl died after being overcome by smoke and flames.
Firefighters from Kearney and Amherst responded to the scene with additional assistance being provided by the Kearney Police Department and the Buffalo County Sheriff’s Office.
It took firefighters about an hour to bring the fire under control.
The State Fire Marshal has been called in to try to determine how the fire started. The Red Cross is providing assistance to the family.
By Brent Wiethorn, KKPR, Kearney